Introduction：
We have developed an integrated antibody humanization and affinity maturation platform based on our advanced Phage/ Yeast display technology and our computer modeling and simulation techniques. Through combining the methods of bioinformatics and structural biology, including in silico CDR-grafting, computer-aided design and optimization, high-throughput screening of Phage-display antibodies, Biacore surface resonance analysis and so on, we are able to provide humanized antibodies with diminished immunogenicity but comparable or better specificity, bioactivity, thermos-stability and productivity than the parental antibodies. The binding affinity of the humanized antibodies can also be further improved at least 5 folds by utilizing our affinity maturation technology.
Competitive Advantageous：
• Extensive experiences: Team with extensive experiences in humanized antibodies design, screening and production.
• In silico design: Effective and reliable antibody modeling and simulating from multiple antibody databases.
• High-throughput screening: Phage/ Yeast display platform.
• Guaranteed affinity: Comparable binding affinity to chimeric antibody; and at least 5 folds improved after affinity maturation.
Product/ Service details：
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Product/ Service |
Deliverable |
Turnaround Time (Business day) |
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Chimeric antibody construction, Antigen-Antibody binding analysis |
ü Top 5 humanized antibodies and their corresponding DNA sequences. ü At least 1 humanized antibody with binding affinity comparable to parental antibody. ü Full report (PDF) |
4-5 months |
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Antibody modeling library construction, Phage/ Yeast displayed antibody library construction |
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High throughput antibody screening |
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Humanized antibody characterization and production |
